Friday, October 9, 2009

NEW STUDY: VBA2C (two cesareans) NOT More Dangerous Than Repeat Cesarean

A new study indicates that VBA2C (vaginal birth after two previous cesareans) is no more dangerous (or safe) than a repeat cesarean section (third cesarean.) This study also shows that while VBA2C can be more risky than a VBA1C, repeat cesarean (second cesarean) carries twice the risks of a first VBAC.

Mothers facing resistance from her care provider over a VBAC or VBA2C should discuss this information with their provider.


SOURCE: BJOG: An International Journal of Obstetrics & Gynaecology

Vaginal birth after two caesarean sections (VBAC-2)—a systematic review with meta-analysis of success rate and adverse outcomes of VBAC-2 versus VBAC-1 and repeat (third) caesarean sections.


Background: Trial of vaginal birth after Caesarean (VBAC) is considered acceptable after one caesarean section (CS), however, women wishing to have trial after two CS are generally not allowed or counselled appropriately of efficacy and complications.

Objective: To perform a systematic review of literature on success rate of vaginal birth after two caesarean sections (VBAC-2) and associated adverse maternal and fetal outcomes; and compare with commonly accepted VBAC-1 and the alternative option of repeat third CS (RCS).
Search strategy We searched MEDLINE, EMBASE, CINAHL, Cochrane Library, Current Controlled Trials, HMIC Database, Grey Literature Databases (SIGLE, Biomed Central), using search terms Caesarean section, caesarian, C*rean, C*rian, and MeSH headings 'Vaginal birth after caesarean section', combined with second search string two, twice, second, multiple.

Selection criteria: No randomised studies were available, case series or cohort studies were assessed for quality (STROBE), 20/23 available studies included.

Data collection and analysis: Two independent reviewers selected studies and abstracted and tabulated data and pooled estimates were obtained on success rate, uterine rupture and other adverse maternal and fetal outcomes. Meta-analyses were performed using RevMan-5 to compare VBAC-1 versus VBAC-2 and VBAC-2 versus RCS.

Main results: VBAC-2 success rate was 71.1%, uterine rupture rate 1.36%, hysterectomy rate 0.55%, blood transfusion 2.01%, neonatal unit admission rate 7.78% and perinatal asphyxial injury/death 0.09%. VBAC-2 versus VBAC-1 success rates were 4064/5666 (71.1%) versus 38 814/50 685 (76.5%) (P < 0.001); associated uterine rupture rate 1.59% versus 0.72% (P < 0.001) and hysterectomy rates were 0.56% versus 0.19% (P = 0.001) respectively. Comparing VBAC-2 versus RCS, the hysterectomy rates were 0.40% versus 0.63% (P = 0.63), transfusion 1.68% versus 1.67% (P = 0.86) and febrile morbidity 6.03% versus 6.39%, respectively (P = 0.27). Maternal morbidity of VBAC-2 was comparable to RCS. Neonatal morbidity data were too limited to draw valid conclusions, however, no significant differences were indicated in VBAC-2, VBAC-1 and RCS groups in NNU admission rates and asphyxial injury/neonatal death rates (Mantel–Haenszel).

Conclusions: Women requesting for a trial of vaginal delivery after two caesarean sections should be counselled appropriately considering available data of success rate 71.1%, uterine rupture rate 1.36% and of a comparative maternal morbidity with repeat CS option.
Accepted 19 July 2009. Published Online 14 September 2009.

AU: Samina Tahseen
AU: Malcolm Griffiths
TI: Vaginal birth after two caesarean sections (VBAC-2)—a systematic review with meta-analysis of success rate and adverse outcomes of VBAC-2 versus VBAC-1 and repeat (third) caesarean sections
SO: BJOG: An International Journal of Obstetrics & Gynaecology
VL: 9999
NO: 9999
YR: 2009
CP: © 2009 The Authors Journal compilation © RCOG 2009 BJOG An International Journal of Obstetrics and Gynaecology
ON: 1471-0528
PN: 1470-0328
AD: Leeds University Hospitals NHS Trust, Leeds, UK; Luton & Dunstable Hospital NHS Foundation Trust, Luton UK
DOI: 10.1111/j.1471-0528.2009.02351.x

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